Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-Associated Virus
نویسندگان
چکیده
منابع مشابه
Characterization of interactions between heparin/glycosaminoglycan and adeno-associated virus.
Adeno-associated virus (AAV) is a key candidate in the development of gene therapy. In this work, we used surface plasmon resonance spectroscopy to study the interaction between AAV and heparin and other glycosaminoglycans (GAGs). Surface plasmon resonance results revealed that heparin binds to AAV with an extremely high affinity. Solution competition studies showed that binding of AAV to hepar...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2013
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi4008676